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CLINICAL DEVELOPMENT PIPELINE

Regulatory Review

Phase III

Phase II

  • Prexasertib (prex” a ser’ tib)
    LY2606368 monomesylate monohydrate (formerly known as Chk1 inhibitor) is a chemical entity that preferentially binds to and inhibits checkpoint kinase 1 (Chk1), a global regulator of the mammalian cell cycle and, to a lesser extent, inhibits Chk2. LY2606368 monomesylate monohydrate is being studied for the treatment of cancer.

    For more information on LY2606368 clinical studies, click here.

    NOTE: If you click on the link above it will take you to a site maintained by a third party, which is solely responsible for its content.



     
  • Galunisertib (gal ue” ni ser’ tib)
    LY2157299 monohydrate (formerly known as TGFb R1 kinase inhibitor) is a chemical entity that selectively blocks transforming growth factor-β receptor I kinase and TGF-b signaling. LY2157299 monohydrate is being studied for the treatment of pancreatic and hepatocellular cancer.

    For more information on LY2157299 clinical studies, click here.

    NOTE: If you click on the link above it will take you to a site maintained by a third party, which is solely responsible for its content.



     
  • Merestinib cancer (mer es’ ti nib)
    LY2801653 (formerly known as c-Met inhibitor) is a chemical entity that has been shown in vitro to be a reversible type II ATP-competitive inhibitor of MET, a receptor for hepatocyte growth factor. Preclinical testing also has shown LY2801653 to inhibit several other receptor tyrosine oncokinases including MST1R, FLT3, AXL, MERTK, TEK, ROS1, and DDR1/2 and the serine/threonine kinases MKNK1/2. LY2801653 is being studied for the treatment of cancer.

    For more information on LY2801653 clinical studies, click here.

    NOTE: If you click on the link above it will take you to a site maintained by a third party, which is solely responsible for its content.



     
  • Edivoxetine (e" di vox' e teen hye" droe klor' ide)
    LY2216684 (edivoxetine) is a chemical entity that inhibits the reuptake of norepinephrine. LY2216684 is being studied for multiple CNS disorders. Molecule is owned by a 3rd party, Lilly retains rights.

    For more information on edivoxetine clinical studies, click here.

    NOTE: If you click on the link above it will take you to a site maintained by a third party, which is solely responsible for its content.



     
  • FGF Receptor Inhibitor
    LY2874455 (FGF receptor inhibitor), a chemical entity, inhibits autophosphorylation of fibroblast growth factor (FGF) receptors 1, 2, 3 and 4, which is required for activation of FGF-induced downstream signaling. LY2874455 is being studied for the treatment of cancer.

    For more information on LY2874455 clinical studies, click here.

    NOTE: If you click on the link above it will take you to a site maintained by a third party, which is solely responsible for its content.



     
  • NOTCH inhibitor cancer
    LY3039478 (NOTCH Inhibitor) is a new chemical entity being studied for the treatment of cancer.

    For more information on LY3039478 clinical studies, click here.

    NOTE: If you click on the link above it will take you to a site maintained by a third party, which is solely responsible for its content.



     
  • PI3 Kinase/mTOR Dual Inhibitor
    LY3023414 (PI3 Kinase/mTOR dual Inhibitor) is a chemical entity being studied for the treatment of prostate cancer and NSCLC.

    For more information on LY3023414 clinical studies, click here.

    NOTE: If you click on the link above it will take you to a site maintained by a third party, which is solely responsible for its content.



     
  • Ralimetinib (ral’’ i me’ ti nib)
    LY2228820 dimesylate (formerly known as p38 MAP kinase inhibitor) is a chemical entity that preferentially binds to and inhibits p38 MAP kinase. LY2228820 dimesylate is being studied for the treatment of ovarian cancer.

    For more information on LY2228820 dimesylate clinical studies, click here.

    NOTE: If you click on the link above it will take you to a site maintained by a third party, which is solely responsible for its content.



     
  • Baricitinib
    atopic dermatitis
    LY3009104 (baricitinib, formerly known as JAK1/JAK2 Inhibitor) is a chemical entity that inhibits the activity of the Janus (JAK) 1 and 2 enzymes. LY3009104 is being studied for the treatment of atopic dermatitis.

    For more information on LY3009104 clinical studies, click here.

    NOTE: If you click on the link above it will take you to a site maintained by a third party, which is solely responsible for its content.



     
  • Baricitinib
    systemic lupus erythematosus
    LY3009104 (baricitinib, formerly known as JAK1/JAK2 Inhibitor) is a chemical entity that inhibits the activity of the Janus (JAK) 1 and 2 enzymes. LY3009104 is being studied for the treatment of systemic lupus erythematosus.

    For more information on LY3009104 clinical studies, click here.

    NOTE: If you click on the link above it will take you to a site maintained by a third party, which is solely responsible for its content.



     
  • Abemaciclib (a be muh sī klib)
    LY2835219 (abemaciclib), a chemical entity, is a selective ATP-competitive inhibitor of cyclin dependent kinases (CDK) 4 and 6 that inhibits phosphorylation of the Rb tumor suppressor protein and thereby induces G1 cell cycle arrest. LY2835219 is being studied for the treatment of squamous NSCLC.

    For more information on LY2835219 clinical studies, click here.

    NOTE: If you click on the link above it will take you to a site maintained by a third party, which is solely responsible for its content.



     
  • Baricitinib
    diabetic nephropathy
    LY3009104 (baricitinib, formerly known as JAK1/JAK2 Inhibitor) is a chemical entity that inhibits the activity of the Janus (JAK) 1 and 2 enzymes. LY3009104 is being studied for the treatment of diabetic nephropathy.

    For more information on LY3009104 clinical studies, click here.

    NOTE: If you click on the link above it will take you to a site maintained by a third party, which is solely responsible for its content.



     
  • Baricitinib
    psoriasis
    LY3009104 (baricitinib, formerly known as JAK1/JAK2 Inhibitor) is a chemical entity that inhibits the activity of the Janus (JAK) 1 and 2 enzymes. LY3009104 is being studied for the treatment of psoriasis.

    For more information on LY3009104 clinical studies, click here.

    NOTE: If you click on the link above it will take you to a site maintained by a third party, which is solely responsible for its content.



     
  • Florbenazine (flor ben' a zeen)
    Florbenazine (18F-AV-133) is a chemical entity PET imaging agent being studied for the imaging of Parkinson's disease pathology.

    For more information on 18F-AV-133 clinical studies, click here.

    NOTE: If you click on the link above it will take you to a site maintained by a third party, which is solely responsible for its content.



     
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Phase I

  • diabetes
    New chemical entity. Molecule is owned by a 3rd party, Lilly retains rights.

     
  • DGAT-2 inhibitor dyslipidemia
    "DGAT-2 inhibitor" is a new chemical entity being studied for the treatment of dyslipidemia.

     
  • BTK inhibitor
    "BTK inhibitor" is a new chemical entity being studied for the treatment of immune diseases.

     
  • BACE inhibitor Alzheimer's
    "BACE Inhibitor" is a new chemical entity being studied for the treatment of Alzheimer's disease.

     
  • D1 potentiator
    "D1 potentiator" is a new chemical entity being studied for the treatment of dementia.

     
  • Pomaglumetad methionil
    LY2140023 monohydrate (pomaglumetad methionil) is a chemical entity agonist of the metabotropic glutamate 2/3 receptors. LY2140023 licensed to Denovo Biopharma to identify genetic biomarkers and to screen for appropriate patient subsets for further study in future clinical trials.

     
  • Chk1 Inhibitor
    "Chk1 Inhibitor" is a new chemical entity being studied for the treatment of cancer. Molecule is owned by a 3rd party, Lilly retains rights.

     
  • Pan-Raf inhibitor
    "Pan-Raf inhibitor" is a new chemical entity being studied for the treatment of cancer.

     
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Pipeline Disclaimer
The information included on this site reflects Eli Lilly and Company's clinical development pipeline and is not intended for promotional purposes. It includes both new molecular entities as well as select new indications or line extensions of currently-approved products, that are in clinical development. There are significant risks and uncertainties in pharmaceutical research and development. Scientific and regulatory hurdles may cause pipeline molecules to be discontinued, delayed or fail to reach the market. There can be no guarantee that pipeline molecules will receive regulatory approval or that they will prove to be commercially successful. Information is current as of July 19, 2016. Lilly assumes no duty to update this information.

For competitive reasons, some pipeline molecules are not identified; in those instances, only the therapeutic area in which the molecule is being studied is listed.
  • NME
  • Select NILEX
  • Diagnostic