[light music in the background throughout]
Voiceover: Hello, Is the dose knob of your Zepbound KwikPen difficult to push? Watch this video for tips on how to prevent this issue and what steps to take.
On-screen text: Lilly [LOGO]
ZEPBOUNDTM KWIKPEN® (TIRZEPATIDE INJECTION)
Troubleshooting Zepbound KwikPen
The dose knob is difficult to push
REFERENCES
1-Zepbound KwikPen Instructions for Use. Eli Lilly Canada Inc.
2-Data on file, Eli Lilly and Company and/or one of its subsidiaries.
Visual: Video title and text appear on the screen
Voiceover: To prevent the dose knob from being difficult to push, start by checking your injection technique. Make sure you prime the Zepbound KwikPen before each injection. This will remove air from the cartridge and ensure your Zepbound KwikPen is working correctly.
On-screen text: How to prevent the dose knob from being difficult to push
Consider the following tips to ensure the ZepboundTM KwikPen® functions as it should:
1. INJECTION TECHNIQUE:
Prime the Zepbound KwikPen before each injection to remove air from the cartridge and to ensure it is working correctly.
Visual: Text appears on screen. Image appears on the right of the screen. Hand holding Zepbound KwikPen between two fingers and thumb is on dose knob pressing the injection button with solution coming out of the KwikPen.
Voiceover: Also, push the dose knob more slowly. This will make it easier to inject.
On-screen text: How to prevent the dose knob from being difficult to push
Consider the following tips to ensure the ZepboundTM KwikPen® functions as it should:
1. INJECTION TECHNIQUE:
Push the dose knob down more slowly as this will make it easier to inject
Visual: Text appears on screen. Image appears on the right of the screen. Hand holding KwikPen and is injecting medicine into abdomen area by pushing the dose knob with the thumb until it stops.
Voiceover: Make sure you are using the pen needles properly. Only press the dose knob when a pen needle is attached because If the flow of the medicine is blocked, increased pressure in the cartridge will cause the red inner seal to bulge.Also, medicine may be wasted, so the full 4 doses may not be received.
On-screen text: How to prevent the dose knob from being difficult to push
Consider the following to ensure the ZepboundTM KwikPen® functions as it should:
2. PROPER NEEDLE USE:
Only press the dose knob when a pen needle, as recommended by your healthcare provider, is attached because:
• If the flow of the medicine is blocked, increased pressure in the cartridge may cause the red inner seal to bulge.
• Medicine may be wasted once a needle is attached resulting in the inability to receive 4 full doses.
Visual: Text appears on screen. Image appears on the right of the screen of hand holding KwikPen with the thumb on the dose knob emphasizing to not press on the dose knob if there is no pen needle attached.
Voiceover: Keep in mind to always attach a new compatible needle to the Zepbound KwikPen before each dose. And ensure the needle is securely attached and is not damaged, bent, or broken. This is important for the medicine to flow properly. The dose knob may be difficult to push if anything blocks or interrupts the flow of medicine in the pen needle.
On-screen text: How to prevent the dose knob from being difficult to push
Consider the following tips to ensure the ZepboundTM KwikPen® functions as it should:
2. PROPER NEEDLE USE:
Always attach a new compatible needle to the Zepbound KwikPen before each dose.
• Confirm the pen needle is securely attached.
• Ensure the needle is not damaged, bent or broken.
Visual: Text appears on screen. Image appears on the bottom of the screen of a zoomed in KwikPen showing the cartridge part and pen needle attached.
Voiceover: Last but not least, the dose knob may become difficult to push if the Zepbound KwikPen is exposed to dust, food, or liquid. If this occurs, throw it away and get a new one.
The Zepbound KwikPen must be stored:
In a clean and dry place.
WITH a cap attached
WITHOUT a needle attached to prevent leaking, blocking the needle, and air entering the KwikPen.
On-screen text: How to prevent the dose knob from being difficult to push
Consider the following tips to ensure the ZepboundTM KwikPen® functions as it should:
3. PROPER ZEPBOUND KWIKPEN STORAGE
The Zepbound KwikPen must be stored:
• In a clean and dry place.
• WITH a cap attached.
• WITHOUT a needle attached, to prevent leaking, blocking the needle, and air entering the KwikPen.
Visual: Text appears on screen. Three images appear on the right of the screen showing liquid, food, and dust with crossed signs on top of the images to emphasize not exposing the KwikPen to dust, food, or liquid.
Voiceover: So, what should be done next? Inspect the Zepbound KwikPen and ensure that it is not damaged.
On-screen text: What to do if the ZepboundTM KwikPen® dose knob is hard to push Inspect the Zepbound KwikPen Ensure it is not damaged.
Visual: Text appears on screen. Image of KwikPen appears in the middle of the screen with magnifier to emphasize inspecting it.
Voiceover: Make sure the red inner seal is intact. If it’s damaged, do not use it.
On-screen text: What to do if the ZepboundTM KwikPen® dose knob is hard to push Make sure the red inner seal is intact. If it’s damaged, do NOT use it.
Visual: Text appears on screen. Image of an intact red inner seal on the KwikPen.
Voiceover: Prepare your Zepbound KwikPen for an injection: Attach a new pen needle.
On-screen text: What to do if the ZepboundTM KwikPen® dose knob is hard to push Attach a new pen needle.
Visual: Text appears on screen. Image of a hand pulling off the paper from the outer needle shield.
Voiceover: Ensure the needle is inserted straight onto the septum and not at an angle, which could tear the septum or cause leakage.
On-screen text: What to do if the ZepboundTM KwikPen® dose knob is hard to push Ensure the needle is inserted straight onto the septum and not at an angle, which could tear the septum or cause leakage.
Visual: Text appears on the screen. Capped pen needle is twisted onto the KwikPen until it’s tight. Outer needle shield is removed and inner needle shied is discarded. Outer needle shield is kept.
Voiceover: Dial the Zepbound KwikPen to the position “0”
On-screen text: What to do if the ZepboundTM KwikPen® dose knob is hard to push Dial the Zepbound KwikPen to the position “0”
Visual: Text appears on screen. Image of a hand turning the dose knob until it stops at “0”.
Voiceover: Press the Zepbound KwikPen dose knob more slowly.
On-screen text: What to do if the ZepboundTM KwikPen® dose knob is hard to push Press the KwikPen dose knob more slowly.
Visual: Text appears on screen. Image appears on the right of the screen. Hand holding Zepbound KwikPen between two fingers and thumb is on dose knob pressing the injection button.
Voiceover: Prime the Zepbound KwikPen by turning the dose knob. You will hear 2 clicks and see a visible long line in the dosing window.
On-screen text: What to do if the ZepboundTM KwikPen® dose knob is hard to push Prime the Zepbound KwikPen.
Visual: Text appears on screen. Image appears on the right of the screen. Forefinger and thumb turn the dose knob until the indicator in the dosing window is on the long hash line. Image of an arrow pointing to an ear flashes in the middle of the screen showing to listen for 2 audible clicks.
Voiceover: The Zepbound KwikPen has been successfully primed if a small amount of medicine comes out of the tip of the needle. It is not necessary to see a stream of medicine to confirm a successful prime.
On-screen text: What to do if the ZepboundTM KwikPen® dose knob is hard to push The Zepbound KwikPen has been successfully primed if a small amount of medicine comes out of the tip of the needle. It is not necessary to see a stream of medicine to confirm a successful prime.
Visual: Text appears on screen. Image appears on the right of the screen. Thumb pushing dose knob to release some medicine into the air until the knob stops. Then slowly counting to 5 while holding the dose knob. Close-up image of needle tip with drop of solution at the tip in the middle of the screen.
Voiceover: Thanks for watching!
On-screen text: Lilly [LOGO]
A MEDICINE COMPANY
VV-Canada Medical-US-DEL-0353©2025 Eli Lilly Canada Inc. All rights reserved
Visual: Lilly logo appears.