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| # **3082-LB** |
| |
| # **The selective amylin analog, eloralintide, enhanced weight-loss efficacy when combined with tirzepatide in diet-induced obese rats.** |
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| **Authors:** Daniel A. Briere1, Libbey O’Farrell1, Cassidy Howard1, Dawn Allen1, Cathy Clutinger1, Tamer Coskun1, Julie S. Moyers1, Amy L. Cox1 |
| |
| 1 Eli Lilly and Company, Indianapolis, IN, USA\ |
| Sponsored by Eli Lilly and Company |
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| **OBJECTIVE** |
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| - To evaluate eloralintide (LY3841136), a long-acting selective amylin agonist, in combination with tirzepatide, a |
| GIP and GLP-1 receptor agonist, for the treatment of obesity in diet-induced obese rats. |
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| **CONCLUSION** |
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| - Combinations of eloralintide and tirzepatide, either as co-administration or adjunctive treatment, led to additive |
| weight loss effects in DIO rats. |
| - These observations support clinical investigation of eloralintide as an obesity therapeutic in combination with |
| tirzepatide. |
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| **CO-ADMINISTRATION – BODY WEIGHT CHANGES** |
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| Simultaneous treatment of eloralintide and tirzepatide enhanced body weight loss in diet-induced obese rats. |
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| **ADJUNCTIVE – BODY WEIGHT CHANGES** |
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| Add-on treatment of eloralintide to tirzepatide dose-dependently enhanced body weight loss in diet-induced obese |
| rats. |
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| **CO ADMINISTRATION - DAILY FOOD INTAKE** |
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| Simultaneous treatment of eloralintide and tirzepatide enhanced daily food intake reductions in diet-induced obese |
| rats. |
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| **ADJUNCTIVE - DAILY FOOD INTAKE** |
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| Add-on treatment treatment of eloralintide and tirzepatide enhanced daily food intake reductions in diet-induced |
| obese rats. |
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| **CO-ADMINISTRATION – % CHANGES AT 4 WEEKS** |
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| Simultaneous treatment of eloralintide and tirzepatide resulted in additive effects on changes in body weight and fat |
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| **ADJUNCTIVE – % CHANGES AT 4 WEEKS** |
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| Add-on treatment of eloralintide to ongoing tirzepatide resulted inadditive effects on changes on body weight and fat |
| mass. |
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| **MATERIALS AND METHODS** |
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| - Co-administration studies: Male Long Evans DIO rats were subcutaneously dosed every 3 days (Q3D) with vehicle, |
| tirzepatide at 30 nmol/kg, eloralintide at 100 nmol/kg, or separate injections of tirzepatide and eloralintide for 4 |
| weeks. |
| - Adjunctive studies: DIO rats were dosed Q3D for 2 weeks with tirzepatide at 30 nmol/kg, followed by addition of 1, |
| 10, or 100 nmol/kg Q3D of eloralintide to ongoing tirzepatide for 2 further weeks. |
| - Body weights and food intake were measured daily. Fat mass measured at baseline and 4 weeks using QNMR. |
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| **RESULTS** |
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| - Co-administration of tirzepatide at 30 nmol/kg and eloralintide at 100 nmol/kg for 4 weeks in DIO rats resulted in |
| additive effects (-20%) on changes in body weight compared to eloralintide (-10%) or tirzepatide (-9%) alone. |
| - For adjunctive treatment, two weeks of tirzepatide at 30 nmol/kg, followed by the addition of eloralintide at 100 |
| nmol/kg for 2 additional weeks, resulted in additive body weight lowering (-21%) compared to eloralintide (-10%) or |
| tirzepatide alone (-9%). |
| - Lower adjunctive combinations of eloralintide (1 & 10 nmol/kg) led to enhanced weight loss (-11% or -15%) versus |
| tirzepatide alone. |
| - This enhanced weight loss was mediated, at least in part, by further and prolonged reductions in daily food intake |
| and reflected in greater changes in fat mass at 4 weeks of treatment. |
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| Scan the QR code for a list of all Lilly content presented at the congress. Other company and product names are |
| trademarks of their respective owners. |
| |
| **Sponsor:** Eli Lilly and Company. |
| |
| **Congress:** American Diabetes Association — 86th Annual Scientific Sessions, New Orleans, LA, USA. 5–8 June 2026. |
| |
| **Poster ID:** 3082-LB. |
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| Copyright © 2026 Eli Lilly and Company. All rights reserved. |
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| title | The Selective Amylin Analog, Eloralintide, Enhanced Weight-Loss Efficacy When Combined With Tirzepatide in Diet-Induced Obese Rats |
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| published-time | 2026-06-25T14:22:46.195Z |
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