Genetic Medicines
Genetic medicines have the potential to transform human health in our lifetime.
Bold Science. Even Bolder Scientists.
Akouos
A leading precision genetic medicine company focused on inner ear disorders.
Prevail Therapeutics
Focused on gene therapies to slow or stop the underlying disease process for people with Parkinson's disease and other neurogenerative disorders.
[Music playing.]
[Red Lilly Logo animation appears on screen on a white background.]
[Black-and-white video shows a man walking in gym shoes on a basketball court. Scenes of men playing basketball.]
00:05-00:29
BILL MCCLEERY
It's really interesting when I play basketball because I don't notice the symptoms when I'm on the court. Sometimes I'll limp into the gym and then get on the basketball court and feel totally normal as I'm running around, and then I'll get done playing and I'll limp out of the gym back to my vehicle. So I don't know if that makes that difference, but there's something that kicks in when you're just dribbling the ball, doing the things that you've done all your life to play that.
[Scenes of men playing basketball transition into a man sitting in his living room. The video transitions from black and white to color.]
00:29-00:57
BILL MCCLEERY
It's just really therapeutic for me, and it just makes the disease not even seem like it's there at that moment. My name is Bill. I was diagnosed at age 50 with Parkinson's disease. Playing basketball as my primary therapy. Twice a week, half court with the guys. I'm the only one that has Parkinson's, and I can still fit into that peer group and play basketball with a group of older guys.
00:57-01:06
BILL MCCLEERY
So I fear or have some trepidation about the time coming that I can't do those sorts of things. I was missing some outside shots.
[A man and woman sit in the stands in the gym watching the basketball game.]
01:06-01:07
AMY MCCLEERY
Well I say good game.
01:07-01:20
BILL MCCLEERY
A good game. All right. Thank you very much.
[A man sitting in his living room.]
They say the non-motor symptoms often come long before the motor symptoms. And I would say I did first experience anxiety and fatigue in the years leading up to my diagnosis and thought something was off.
[A woman is sitting in the living room talking. Video shows scenes of the couple walking and talking.]
01:20-01:36
AMY MCCLEERY
We used to walk together. We would walk a couple of miles every night, and then it got to a point where his toes curl. And so we really got to the point we could not work together. Like that was kind of our time. At the end of the day, you know, it was kind of a grieving process of, we can't do this together.
01:37-01:39
AMY MCCLEERY
But then we just started to find like other things that we could do.
01:39-01:45
BILL MCCLEERY
We'll be holding hands and I squeeze a little bit too hard just without meaning to. And she'll be like, ouch. And loosen up a little bit on the hand-holding.
[Video shows scenes of the couple cooking together and eating dinner with their daughter.]
01:45-01:58
AMY MCCLEERY
We were in a doctor's office and we saw someone in the later stages. The older gentleman was in a wheelchair. At some point, maybe that's or maybe that's in our future, I don't know. We'll figure that out when we get there.
[Video of a man using a computer]
01:58-02:08
BILL MCCLEERY
You know, I'd love to think that there's some research happening somewhere that's going to lead to a great breakthrough. And I'm definitely interested in whether genetic science can be the premise of a cure for Parkinson's.
[Video transitions to a man in a blue suit coat being interviewed in an office setting. Scenes of the man working in the lab are shown.]
02:08-02:26
ANDREW ADAMS
With these kinds of progressive diseases where your brain is degrading, we need to actually focus on what's the root cause and address the root cause of those diseases. And that's where genetic medicine comes in, because we don't want to do incremental things where we target symptoms. What we're looking to do here is make transformational medicines.
[Video transitions to a woman in a dark red jacket being interviewed. Video shows scenes of scientists working in a lab.]
02:26-02:50
MICHELLE LYNN HALL
Genetic medicine is basically doing everything that a lot of the medicines have done for years, but very intentionally focusing on treating and curing diseases at their foundational and root level. You come into your health care provider’s office, and we would give you a treatment that would get into your cells, get into the nucleus, and fundamentally correct a pathogenic mutation in your DNA.
02:50-03:04
MICHELLE LYNN HALL
And you would be done. I'm here because I think the most impactful thing I could do as a scientist in my career is create cures and treatments for debilitating neurodegenerative diseases like ALS, like Alzheimer's, like Parkinson's.
[Video transitions to a man on a porch swing talking with his daughter.]
03:04-03:06
HANNAH MCCLEERY
How have you been dealing with all the symptoms and everything?
03:07-03:18
BILL MCCLEERY
I'm pretty good. Take my meds. like, my left hand acts up now and then. But I'm just glad that my left hand on my right. Yeah, that's not my shooting hand playing basketball. Yeah.
03:18-03:20
HANNAH MCCLEERY
To make the three pointers.
[Video transitions to show a man sitting in his living room. Video shows scenes of the man filling up a bird feeder in his yard, and we then see him back on the basketball court.]
03:20-03:45
BILL MCCLEERY
That's right. With three daughters I do look forward to things like being part of their weddings. being part of grandkids someday. I don't think Parkinson's has to be a barrier or an impediment to that. I look to the future and plan on being there and being active and being part of things for years to come. One thing I've told my neurologist is that if she'd like to become famous by becoming the person to cure Parkinson's, I'll volunteer to be the person she cures it in.
03:45-03:54
BILL MCCLEERY
I mean, I do hope there's a cure someday, whether it benefits me or generations down the road. So I'm hopeful. I hope to be able to continue that and to stay positive no matter what.
[Red Lilly logo appears.]
[Music fades in the background.]
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