For adults with obesity, or with overweight in the presence of at least one weight-related comorbid condition, in combination with a reduced-calorie diet and increased physical activity
Foundayo is not indicated for cosmetic weight loss.
Zepbound should not be used for cosmetic weight loss.
Beginning July 1, millions of eligible Medicare Part D patients can pay no more than $50 per month* for FoundayoTM (orforglipron) or Zepbound® (tirzepatide)1,2
These eligibility criteria are Medicare GLP-1 Bridge defined access requirements and may not reflect the Foundayo or Zepbound product labels or clinical trial populations.
For eligible Medicare patients with a Foundayo or Zepbound prescription. This information is not a guarantee of coverage. Actual eligibility will be determined by Medicare GLP-1 Bridge eligibility criteria. Visit https://www.cms.gov/medicare/coverage/prescription-drug-coverage/medicare-glp-1-bridge to learn more.
INDICATION
Foundayo is indicated in combination with a reduced-calorie diet and increased physical activity to reduce excess body weight and maintain weight reduction long term in adults with obesity or adults with overweight in the presence of at least one weight-related comorbid condition.
Limitations of Use: Concomitant use with another GLP-1 receptor agonist is not recommended.
In products with glucagon-like peptide-1 (GLP-1) receptor agonist activity that are pharmacologically active in rats and mice, rodent thyroid C-cell tumors (adenomas and carcinomas) have been observed at clinically relevant exposures and are considered GLP-1 receptor-dependent effects in rodents. Orforglipron is not pharmacologically active in rats or mice and did not produce tumors in rodents. While orforglipron is pharmacologically active at the human GLP-1 receptor, the human relevance of GLP-1 receptor-dependent thyroid C-cell tumors observed in rodents has not been determined.
Foundayo is contraindicated in patients with a personal or family history of medullary thyroid carcinoma (MTC) or in patients with Multiple Endocrine Neoplasia syndrome type 2 (MEN 2). Counsel patients regarding the potential risk for MTC with the use of Foundayo and inform them of symptoms of thyroid tumors (e.g., a mass in the neck, dysphagia, dyspnea, persistent hoarseness). Routine monitoring of serum calcitonin or using thyroid ultrasound is of uncertain value for early detection of MTC in patients treated with Foundayo.
INDICATIONS
Zepbound is indicated in combination with a reduced-calorie diet and increased physical activity:
- to reduce excess body weight and maintain weight reduction long term in adults with obesity or adults with overweight in the presence of at least one weight-related comorbid condition.
- to treat moderate-to-severe-obstructive sleep apnea (OSA) in adults with obesity.
Limitations of Use: Zepbound contains tirzepatide. Coadministration with other tirzepatide-containing products or with any glucagon-like peptide-1 (GLP-1) receptor agonist is not recommended.
WARNING: RISK OF THYROID C-CELL TUMORS
In rats, tirzepatide causes dose-dependent and treatment-duration-dependent thyroid C-cell tumors at clinically relevant exposures. It is unknown whether Zepbound causes thyroid C-cell tumors, including medullary thyroid carcinoma (MTC), in humans as human relevance of tirzepatide-induced rodent thyroid C-cell tumors has not been determined.
Zepbound is contraindicated in patients with a personal or family history of MTC or in patients with Multiple Endocrine Neoplasia syndrome type 2 (MEN 2). Counsel patients regarding the potential risk for MTC with the use of Zepbound and inform them of symptoms of thyroid tumors (e.g., a mass in the neck, dysphagia, dyspnea, persistent hoarseness). Routine monitoring of serum calcitonin or using thyroid ultrasound is of uncertain value for early detection of MTC in patients treated with Zepbound.
1. Sexton Ward A, Tysinger B, Nguyen P, Goldman D, Lakdawalla D. Benefits of Medicare coverage for weight loss drugs. USC Leonard D. Schaeffer Institute for Public Policy & Government Service. Published April 18, 2023. Accessed March 16, 2026. https://schaeffer.usc.edu/research/benefits-of-medicare-coverage-for-weight-loss-drugs/
2. Centers for Medicare & Medicaid Services (CMS). Medicare GLP-1 Bridge. Updated April 21, 2026. Accessed April 22, 2026. https://www.cms.gov/medicare/coverage/prescription-drug-coverage/medicare-glp-1-bridge
3. Federal Interagency Forum on Aging-Related Statistics. Older Americans: key indicators of well-being. Published May 2024. Accessed February 4, 2026. https://agingstats.gov/docs/LatestReport/Older-Americans-2024-508-May-update.pdf