Scientific Areas of Interest

What's under the microscope, and beyond.

The discovery of new medicines is about being relentless. You will gain access to Lilly development team with decades of experience dedicated to exploring every avenue necessary.

We never stop searching for:

  • Medicines that are novel, tailored and differentiated from the current standard of care.
  • New ways to address unmet medical needs.
  • Treatments, therapies, technologies and devices that generate better outcomes for payers, providers, prescribers and patients.

And it's all done with a true sense of urgency, ensuring our medicines reach patients as soon as possible.

  • Oncology

    At Lilly Oncology, we are looking for enabling therapeutic development platforms, breakthrough monotherapy programs, and opportunities for rational combinations with our existing pipeline.

    Our greatest oncology interests lie in novel assets in the following areas:

    • Novel immuno oncology approaches—T-cell redirection, novel checkpoint agents, and neo-antigen based therapies
    • Agents targeting the tumor microenvironment and interplay between the microenvironment and immune system
    • Cancer-signaling modulators targeting genetically defined populations
    • Tumor metabolism pathway modulators
    • Epigenetic modulators

    Neither the content nor any other service presented here is intended to be relied on for medical diagnosis or treatment.

    Click here Oncology 01.2017for PDF version.

  • Neuroscience

    Our greatest interests include:

    Neurodegenerative Diseases

    • Novel therapeutic approaches for disease modification in neurodegenerative diseases, especially Alzheimer’s disease and Parkinson’s disease
    • Novel treatments that address the symptoms of neurodegenerative disease including psychosis, cognitive impairment, agitation, mood and sleep
    • Blood-based biomarkers for early detection of amyloid-positive dementia
    • Wearable technologies and smartphone applications for early detection of Alzheimer's disease intiation and progression

    Pain and Migraine

    • Novel approaches to treat chronic neuropathic, inflammatory and visceral pain
    • Migraine prophylaxis

    Neither the content nor any other service presented here is intended to be relied on for medical diagnosis or treatment.

    Click Neuroscience 01.2017 for PDF version.

  • Diabetes and Diabetes-Related Complications

    Our greatest interests lie in the following areas:

    Insulins and Glucagon:

    • Next-generation insulins (basal, ultra-rapid, high-concentration, thermostable)
    • Glucose-responsive/sensing insulin
    • Soluble glucagon
    • Increlins: Insulin + various incretin/GCG combinations, especially with weight loss potential


    • Novel GLP-1 and dual-acting GLP-1 mimetics and novel combinations with potential for CV benefits


    • Novel approaches relevant to the development of an artificial pancreas
    • Oral peptide/protein delivery platforms and therapeutics
    • Breakthrough diabetes device technology

    Diabetic Complications:

    • Islet health Insulin sensitizers, beta cell regeneration/trans-differentiation agents and diabetes remission
    • Diabetic kidney disease Pathways and mechanisms related to inflammation, endothelial dysfunction, remodeling, alteration of tissue metabolism, cellular energetics and fibrogenesis
    • NAFLD/NASH Full spectrum of the disease and intersecting pathways of fuel metabolism, inflammation and fibrosis
    • Diabetic dyslipidemia with CV benefits Agents that have beneficial effects on muliple lipid/vascular risk factors such as triglyceride, LDL-C and Lp(a)
    • Heart failure HFrEF and HFpEF; novel mechanisms that can be used in conjunction with existing starndard of care. Areas of focus include targets that impinge on cardiac substrate utilization and metabolism, and those that impact remodeling

    Novel Platforms:

    • RNAi, translational modulators, cell-based therapy (e.g., for T1DM, heart failure), microbiome modulators

    Other Areas:

    • Type 1 Diabetes
    • Endocrine disorders (e.g., growth disorders and major unmet medical needs)
    • Neuropathic pain (intersects with our Pain TA)
    • Novel mechanisms: Especially in the private sector, new/emerging companies and/or mechanisms that are not addressed above
    • Differentiation is key. Highest priority is given to validated 'Glucose-Plus' agents (i.e., drugs that reduce HbA1c and elicit .10% weight loss and/or improvements in other CV risk factors); essentially therapeutics that can mimic bariatric surgery-like effects

    Out of Scope:

    • Insulin secretagogues with no added metabolic benefits
    • Wound healing
    • Gastroparesis
    • Anticoagulants
    • Acute myocardial infarction/ischemia-reperfusion therapies
    • Acute/ischemic stroke
    • Arrhythmia
    • Peripheral arterial disease

    Neither the content nor any other service presented here is intended to be relied on for medical diagnosis or treatment.

    Click Diabetes and Diabetes-Related Complications 01.2017for PDF version.

  • Immunology

    The immunology platform’s mission is to address unmet medical needs with best-in-disease or best-in-class medicines and to deliver unparalleled customer experiences—with a strong focus on small molecule and biologics in the following indications:

    Indications in Scope:

    • Rheumatoid arthritis
    • Psoriasis
    • System lupus erythematosus
    • Crohn’s disease
    • Ulcerative colitis
    • Ankylosing spondylitis
    • Psoriatic arthritis
    • Lupus nephritis
    • Atopic dermatitis

    Technologies in Scope:

    • Interested in small molecule NMEs with biologic efficacy, and no increased safety risk
    • Microbiome
    • Antibodies that have a durable MOA with a greatly improved clinical efficacy over standard of care
    • Nanoparticles for use in tolerance

    Out of Scope:

    • Intergin targets
    • Biosimilars

    *Neither the content nor any other service presented here is intended to be relied on for medical diagnosis or treatment.*

    Click Immunology 01.2017for the PDF version.

  • Emerging Technology and Innovation

    The Emerging Technology and Innovation team complements therapeutic area-specific external research efforts by providing distinct geographic coverage plus access to novel pathways and new therapeutic modalities. We specialize in connecting partners to Lilly expertise and deploying flexible funding models. The team comprises experienced drug discovery and development scientists based in Cambridge, MA (external research hub established 2016), Indianapolis and Europe, with additional members in Japan. New opportunities of interest include pan-therapeutic and adjacent disease areas (as well as added support for Lilly’s core therapeutic areas). We are committed to collaboration with premier universities, investigators and companies around the world to advance innovation, enhance Lilly’s pipeline and improve patient outcomes.

    Our greatest interests lie in the following areas:

    Novel biologic pathways: Emphasis on those with multi-therapeutic area potential.

    • Examples include: micro-RNA; exosome biology; epigenetics

    Adjacent disease areas:

    • Examples include: fibrosis, kidney disease, vascular disease, other disorders of immune function, broader neurologic conditions

    Disruptive technologies:

    • New therapeutic modalities (including but not limited to oligonucleotide-based approaches; gene editing; gene therapy; microbiome; cell-based approaches)
    • Novel approaches to “drug” difficult targets (e.g. cell-penetrant peptide platforms)

    Alternative funding and partnering models: This team has expertise in—and access to—flexible funding models for advancing exciting science.

    • Strategic limited partnerships in world-class venture funds. These funds work with scientific and business leaders to advance breakthrough innovation. A key strategy involves early development funding and cofunding opportunities (emphasis on leveraging Lilly’s Chorus* organization)
    • Direct equity investments in selected biotechnology companies
    • “Build-to-buy” investments
    • Other “shared-risk” drug discovery and early development relationships

    * Chorus is a fully integrated early stage drug development team whose scope includes IND-enabling preclinical studies through Phase 2 development. Chorus specializes in delivery of rapid, efficient and cost–effective clinical proof-of concept results. The team has extensive experience in developing externally derived molecules in partnership with selected VC firms (including HealthCare Ventures, TVM Capital, Atlas Ventures).

    Neither the content nor any other service presented here is intended to be relied on for medical diagnosis or treatment.

    Click Emerging Technology and Innovation 01.2017 for PDF version.

  • Biotechnology Discovery Research

    Our greatest interests lie in the following areas:

    Biotherapeutic Discovery and Validation:

    • Antibody discovery: in vitro and in vivo
    • Antibody screening platforms; e.g., microfluidics
    • Novel immunization platforms
      • Ion channels
    • Bi-specific/multi-functional platforms
    • Alternative antibody scaffolds
    • Protein engineering
    • Translational cell-based platforms – 3D culture; e.g., 3D printing – ‘organ on a chip’ nanotechnology
    • iPS cell differentiation
    • Vascular endothelial cell biology

    Biotherapeutic Optimization:

    • Protein expression/production technologies – Non-mammalian/microbial expression and production systems – Cell line generation – Cell culture – Antibody/Fab production systems
    • Purification processes
    • Glycosylation, including non-mammalian
    • Peptide chemistry – Semi-synthetic or recombinant – Non-natural amino acid incorporation
    • Protein: protein interactions – Macrocyclics
    • Peptide/Protein drug conjugates
      • Novel linker/conjugation chemistries
    • Time extension of antibodies, peptides and proteins
      • Size: alternatives to PEG-ylation
      • Controlled release
    • Site-specific chemical modification
    • Biophysical analysis
      • Mass spectrometry data analysis tools
      • Charaterization of particle mass, composition, morphology; i.e., .1 um
      • Protein structure at higer resolution than CD, FTIR, etc.
      • Automated formats for existing biophysical techniques; e.g., static light scattering
      • Protein colloidal stability/protein-protein interactions at .100+mg/mL

    Biotherapeutic Formulation/Delivery:

    • Oral
      • Permeation enhancers, receptor-mediated transcytosis, nanotechnologies
    • Blood Brain Barrier
    • Capillary endothelial barrier
    • Pericellular junctions (subQ delivery)
    • Intracellular targeting
    • Formulation design
      • Excipients, co-formulations, nanotechnologies
    • Devices
    • In vivo targeted delivery of nucleic acid-based molecules

    Neither the content nor any other service presented here is intended to be relied on for medical diagnosis or treatment.

    Click Biotechnology Discovery Research 01.2017 for PDF version.

  • Drug Delivery and Devices

    Our greatest interests lie in device and delivery solutions for Diabetes, Alzheimer's, Immunology, Pain, and Oncology, with a specific focus in the following areas:

    Connected Product Systems:

    • Connected injection devices
    • Next-generation miniaturized electronics (sensing, power, communications, processing)
    • Robust analytics platforms that provide an actionable insights
    • Novel, low-cost, real-time, non-or minimally invasive biosensing or digital biomarker platforms
    • Personalized, prescriptive algorithms/machine learning for disease management
    • Technology-enabled services to support customer achieving better outcomes
    • Data integration platform technologies that securely integrate disparate health and contextual data sources to enable a connected ecosystem that achieves better outcomes at lower cost and higher quality
    • Medial algorithms for use in moblie medical applications

    Biologic Delivery:

    • Formulation technology to reduce visosity and/or enhance stability of biologics
    • Needle-free delivery technologies
    • Time-action modulation (small and large molecules)
    • Preservation technology to enable multi-use biological preps
    • Device technology, including body-worn devices, to rapidly deliver high-volume (>2ml) and/or high-viscosity (>10 cpd) biologic solutions
    • Multi-pharmacology delivery systems, including fixed-dose combinations and bi-specific or combined dose antibodies
    • Technologies to increase concentration of proteins
    • Longer stabilization or eliminated/reduced preservative insulin technologies

    Oral Biologic Deliver:

    • Formulation technology
    • Molecular engineering
    • High oral bioavailability system for large(r) molecules

    Neither the content nor any other service presented here is intended to be relied on for medical diagnosis or treatment.

    Click Drug Delivery and Devices 01.2017 for PDF version.

  • Emerging Markets

    Our greatest interests lie in the following areas:

    In-Licensing and Co-Development


    • Thoracic cancer and breast cancer
    • Gastrointestinal: Gastric, colorectal, hepatocellular carcinoma, pancreatic cancer
    • Immuno-oncology


    • Rheumatoid arthritis
    • Psoriasis, psoriatic arthritis, anklyosing spondylitis
    • System lupus erythematosus, lupus nephritis
    • Crohn's disease and ulcerative colitis


    • Neurodegenerative Disorders: Approaches that affect disease progression or modification and/or address major symptoms of the disease
    • Pain and Migraine


    • Glucose and metabolic control: ultra rapid-acting insulins, novel oral anti-diabetic agents, novel insulin sensitizers
    • NASH
    • Endocrine disorders (e.g., growth disorders)
    • Connected Product systems: Connected injection devices, analytics platforms that provide actionable insights

    Neither the content nor any other service presented here is intended to be relied on for medical diagnosis or treatment.

    Click Emerging Markets 01.2017 for PDF version.

  • Chorus

    Chorus is a fully-integrated Lilly R&D unit with the ability to be a strategic development partner for external programs.

    • Full-service, autonomous R&D unit within Lilly
    • Specializes in drug development from candidate selection to clinical proof-of-concept (PoC)
    • Focuses only on those experiments that can provide quick go/no go decisions and create strong PoC data packages
    • Pulls risk forward and increases marketability of the development program by implementing development work that drives the largest change in technical probability of success and greatest value in the shortest time

    The Chorus lean-and-efficient model improves productivity in both time and cost compared to average pharmaceutical R&D metrics. Since its creation in 2002, Chorus has completed more than 50 internal Lilly and external-sponsored programs in various clinical indications in 19 countries.

    Neither the content nor any other service presented here is intended to be relied on for medical diagnosis or treatment.

    Click Chorus 01.2017 for PDF version.

  • Animal Health

    At Elanco, we provide those who raise and care for animals with solutions that empower them to advance a vision of food and companionship enriching life.

    We understand the powerful role healthy animals play in making lives better. As pets increasingly become important parts of our families, so too does the need to help them live longer, healthier, higher-quality lives. As the global population grows, so too will the need to meet the demand for safe, affordable food for all.

    Since our start at Eli Lilly and Company in 1954, Elanco has been working to empower our customers—from veterinarians to food producers to all those concerned with animal health—to address these global challenges, and advance a vision of food and enriching life. We strive to develop and deliver products safe for consumers, animals and the environment through innovation and a shared vision to enrich the lives of people worldwide.

    External Innovation: Elanco’s partnership engine providing rapid evaluation of external opportunities for both Companion and Food Animals.

    Partnering with Elanco:

    • Global presence in food animal and companion animal markets
    • Significant sales and marketing capabilities in health and nutrition
    • Extensive R&D capabilities with an innovative pipeline and approach
    • Create alternative revenue streams and discover unrealized commercial value

    Animal Health Licensing:

    • Potentially faster route to market/income to support additional development efforts
    • Rapid proof of concept in the target species
    • Opportunities that fail in human health may become successful animal health products through re-purposing and may provide extended patent life

    Food and Companionship Enriching Life Focused R&D Efforts Elanco Table Picture

    Neither the content nor any other service presented here is intended to be relied on for medical diagnosis or treatment.

    Click Animal Health 01.2017 for PDF version.

  • Discovery Chemistry Research and Technologies

    Discovery Chemistry Research & Technologies (DCRT) invents and discovers new molecules that can become medicines. These molecules must have the right characteristics to test innovative therapeutic hypotheses and be differentiated from those of our competitors. To achieve this, DCRT works with all therapeutic areas to choose the right biological targets whose manipulation may lead to positive patient outcomes. DCRT brings together many different scientific disciplines to design, prepare, and select the best molecular scaffolds for optimization, with the ultimate goal of delivering a single molecule that has the best combination of attributes to be tested in the clinic.

    Our greatest interests lie in the following areas:

    Molecule Design & Identification:

    • In silico & related technologies
    • Computational chemistry
    • Cheminformatics & bioinformatics
    • Analytical methodologies & instrumentation
    • Complementary chemical diversity
    • DNA-encoded libraries
    • Oral strategies for high MW molecules
    • Protein: Protein interaction inhibitors

    Molecule Synthesis & Optimization:

    • Automation hardware & software

    Biological Testing:

    • Human disease-relevant in vitro cell-based assays
    • Novel biological targets & assay approaches
    • Structural biology and biophysical methods to study Mode of Action
    • Chemoproteomics
    • Biophysical technologies

    Neither the content nor any other service presented here is intended to be relied on for medical diagnosis or treatment.

    Click Discovery Chemistry Research and Technologies 01.2017 for PDF version.

  • Lilly-San Diego Collaborative Research

    The Lilly Biotechnology Center in San Diego (LBC-SD) is seeking academic and biotechnology partners interested in leveraging our protein discovery and engineering capabilities to advance research on novel therapeutic targets and pathways into clinical translation. With our ability to create a large molecule diversity via robust antibody and peptide discovery technologies, a collaboration with LBC-SD allows the rigorous interrogation and validation of novel targets. Our engineering capabilities allow pursuit of flexible strategies of multi-parameter optimization to solve key issues with pharmacology, drugability and down-stream developability spanning traditional scaffolds to next-generation multifunctionals. These varied scaffolds (including antibodies, hormones, cytokines and enzymes) have successfully been applied to a broad range of clinical targets.