Lilly has been a global leader in diabetes care for more than 140 years and remains strongly committed to innovation in diabetes research and beyond.

Indications of interest include:

• Diabetes

• Obesity / metabolic health and related indications (e.g., cachexia, sarcopenia, bone-health, longevity-related indications, rare endocrinological diseases)

• Heart failure (HFpEF and HFrEF) and related indications (e.g., hypertension, pulmonary arterial hypertension)

• Chronic kidney disease (Stage 3b-4)

• Atherosclerotic cardiovascular disease

We are also broadly interested in the following:

Technologies: Novel peptide delivery (e.g., oral / sustained-release formulations or ingestible devices) or tissue/organ targeting (e.g., beta cells, skeletal muscle)

Targets: New targets via genetic/-omics and AI/ML approaches

Specific areas of interest by indication are listed below.

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Diabetes

Specific areas of interest:

• Beta-cell boosters/ improvement in beta-cell health and function

• Islet cell therapy

• Next-gen immunomodulation

• Glucose-sensing or reduced-hypo insulin

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Obesity / Metabolic Health and Related Indications

MoAs of interest:

• GLP-1/incretin add-ons

• Body composition (e.g., preservation/promotion of lean body mass)

• Energy expenditure

• Mitochondrial health

• Durability/set-point modulation

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Heart failure and related indications

MoAs of interest:

• Next generation oral / injectable approaches on myocardium and heart function, e.g., mitochondrial function, inflammation, regeneration

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Chronic Kidney Disease

MoAs of interest:

• Remodeling / regeneration of tissue

Technologies of interest:

• Delivery to specific kidney cell types/structures

Lilly has a growing portfolio of solutions for patients in dermatology, rheumatology, and gastroenterology.

Indications of interest include:

Dermatology

• Atopic dermatitis

• Psoriasis

• Hidradenitis suppurativa

• Pemphigus vulgaris

Rheumatology

• Rheumatoid arthritis

• Psoriatic arthritis

• Spondyloarthropathy (PsA, axSpA)

• Systemic lupus erythematosus

Gastroenterology

• Crohn’s disease

• Ulcerative colitis

• Eosinophilic esophagitis

• Celiac disease

Other

• Fibrosis (e.g., IPF, SSc)

• Progressive forms of multiple sclerosis

• T1DM

• Areas of high unmet need

Our additional areas of interest include:

• Nanoparticles for use in immune tolerance

• Protein knockdown (e.g., siRNA, protein degradation)

• Tissue-targeted delivery platforms

• Cellular therapeutics

• Microbe-derived molecules

• Precision medicine

Lilly is committed to finding medicines for the treatment of neurodegenerative diseases and chronic pain.

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Neurodegeneration

Indications of interest:

• Alzheimer’s Disease

 

• Parkinson’s Disease

  

• Amyotrophic Lateral Sclerosis (ALS)

  

• Other related proteinopathies (e.g., Huntington’s, progressive supranuclear palsy, multiple system atrophy, frontotemporal dementia)

• Related monogenic neurodegenerative conditions (e.g., lysosomal storage disorders, leukodystrophies)

• Other neurological diseases

MoAs of interest:

• Inhibition of protein misfolding, accumulation, and aggregation, and spread

• Innate immune response and neuroinflammation

• Proteostasis

• Inhibition of neuro-, axonal- and synaptic degeneration

• Symptomatic treatments with clinical evidence (e.g., psychosis, cognitive impairment, agitation, mood, movement, sleep)

Technologies of interest:

• Blood-brain-barrier delivery

• Protein knockdown (e.g., siRNA, protein degradation)

• Exon splicing modulation

• Gene therapy and editing

• Blood-based biomarkers for Alzheimer’s or Parkinson’s disease

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Pain

Indications of interest:

• Chronic neuropathic pain (e.g., diabetic peripheral neuropathic pain, neuropathic back pain, post-traumatic neuropathic pain, multiple sclerosis pain)

• Musculoskeletal pain (e.g., osteoarthritis, chronic low back pain, degenerative disc disease, fibromyalgia)

• Visceral pain (e.g., irritable bowel syndrome, functional dyspepsia, residual pain in inflammatory bowel disease)

• Migraine and other forms of disabling headache

• Peripheral neuropathies

• Neurological disorders characterized by neuronal hyperexcitability

MoAs of interest:

• Symptomatic relief of pain and improvement of function

• Prevention or repair of peripheral nerve damage and neuropathies

• Damage prevention or joint repair in musculoskeletal disease

Technologies of interest:

• Delivery (e.g., blood-brain barrier, peripheral nerves)

• Protein knockdown or modulation (e.g., siRNA, gene therapy, protein degradation)

Loxo Oncology at Lilly is actively seeking partnerships with world-class industry and academic collaborators in order to optimize and accelerate the development of new cancer medicines. We are focused on opportunities across discovery and development stage assets with the potential to:

• Demonstrate unequivocal activity early in the drug development process

• Deliver outsized and differentiated effects for patients

We are agnostic to the biologic basis of programs, so long as we have high conviction in the science and believe they will matter for patients. Find more information about Loxo Oncology at Lilly here.

Lilly is committed to advancing genetic medicine therapeutics by fostering innovation and transformational science. We look to expand our pipeline within and beyond our core therapeutic areas of interest and serve the unmet needs of patients, including adjacent comorbidities.

Technologies of interest:

• Novel delivery and expression methods (e.g., viral and non-viral vectors, promoters and other regulatory elements, nanocarriers)

• Genome editing tools

• Oligonucleotide therapeutics (e.g., ASOs, small RNA platforms, mRNA therapeutics, gene replacement)

• Novel routes of administration (e.g., device assisted delivery, cell/tissue-specific bioconjugates)

• Solutions that can improve the specificity, potency, and toxicity profiles of our molecules (e.g., AI, non-animal models)

Targets of interest:

• Heritable gene mutations

• Gene-environment interactions-based targets (e.g., epigenetic)

• Functionally curative targets

Lilly is excited to support innovative medicines with cutting edge digital technology.

We are broadly interested in the following across our pipeline and indications:

• Validated digital biomarkers and endpoints: To measure safety/efficacy or medications, including technologies that enable development of novel digital biomarkers

• Patient-facing drug companion application/digital solutions (medication initiation to medication management): For adherence, management/monitoring of comorbidities/side effects, titration optimization, dosing optimization, outcomes measurement

• Clinical devices (approved / ready for research): Connected vitals devices (e.g., BP, HR, pulse ox, temp), connected ECG devices (multi-lead)

• Clinical software / applications: Telemedicine app/SaaS with auto-translations, “virtual” and on-demand Clinical Service Providers, adjudication management software, multi-system security manager to enable SSO, EMR/EHR integration software (between Clinical Research data collection and EMRs), central certification/mutual recognition for imaging centers for research, compliant and research-ready calendaring and messaging

We are broadly interested in novel platforms across most indications.

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Biologics

Protein platforms of interest:

• Antibody discovery

• Antibody engineering

• AI/ML applications to drug discovery and development

• De novo protein design

• GPCR and multi-pass transmembrane proteins

• Conjugation

Other delivery technologies of interest:

• Oral delivery of large molecules

• BBB transporters

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Synthetic Molecules

Novel synthetic molecule drug development methods of interest:

• Conjugate manufacturing and development (e.g., ADC, ARC)

• Oligonucleotide manufacturing capabilities

• Continuous manufacturing capabilities

Other technologies of interest:

• Delivery technologies (e.g., lipid nanoparticle, oral peptide)

• Small molecule RNA modulation

• Antibody / drug conjugation (linker / payload)

• Novel ligand identification

• Small molecule discovery via AI / AL methods

• Protein degradation technology (e.g., PROTAC, molecular glue)